Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is certainly an impurity associated with bortezomib, a proteasome inhibitor used in the therapy of numerous myeloma. Its synthesis or analyze is important for making certain the purity and protection on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor in the synthesis of abiraterone acetate, a drug Utilized in the remedy of prostate most cancers by inhibiting androgen creation.
Imatinib Intermediate (CAS NO. 152460-ten-1): A critical compound while in the synthesis of imatinib, a drug that targets precise forms of cancer, like Persistent myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats different cancers which include breast, lung, and prostate most cancers.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are generally intermediates in the synthesis of gemcitabine, an anti-most cancers drug. Their analyze is vital for optimizing the generation method and making sure higher purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is made use of to deal with breast most cancers, and these intermediates are associated with its generation.
Fulvestrant Intermediates: Fulvestrant is CAS NO. 848133-35-7 definitely an estrogen receptor antagonist Utilized in the procedure of breast cancer. Different intermediates help in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is Utilized in the synthesis of paclitaxel, a chemotherapy drug productive in managing cancers such as ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug Utilized in the treatment method of colorectal cancer and modest mobile lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-82-9): This compound is involved in the synthesis of adamantane derivatives, which have many programs, like antiviral Houses.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral drug for style two diabetic issues that inhibits the enzyme DPP-four to control blood sugar concentrations.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 3-dihydroisoindol-2-yl)piperidine-2 61259-forty eight-1): This compound is associated with the synthesis of various gluconic acid derivatives, that happen to be Utilized in foods, pharmaceutical, and industrial programs.
Canagliflozin Intermediate 2: A precursor in the synthesis of canagliflozin, a medication utilized to manage style two diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).